Andy Murray and Stan Wawrinka were bundled out of the Monte-Carlo Masters on Thursday, but Novak Djokovic and Rafael Nadal reached the quarter-finals in contrasting fashion.
Albert Ramos-Vinolas fought back from 4-0 down in the final set to claim the scalp of top seed Murray, who went down 2-6 6-2 7-5 on the clay in the principality.
The world number one was not the only big name to bow out, as US Open champion Wawrinka was beaten 6-4 6-4 by Pablo Cuevas.
Twelve-time grand slam champion Djokovic showed he still has work to do in order to return to the peak of his powers, but saw off Pablo Carreno Busta 6-2 4-6 6-4.
Fourth seed and defending champion Nadal only needed 68 minutes to beat birthday boy Alexander Zverev 6-1 6-1.
MURRAY RUES 'BAD DECISIONS'
Murray looked bound for the last eight when he won the first four games of the deciding set, but the three-time grand slam champion was left stunned by a defiant Ramos-Vinolas.
The top seed grew increasingly disgruntled in the final set as Spaniard Ramos-Vinolas turned the tide to seal the biggest victory of his career and book a last-eight meeting with Marin Cilic.
Wimbledon champion Murray said: "A few times, I made some bad decisions. That's something that, with my team, I'll look at, watch some parts of the match over, see the shots that I chose and what I would do differently."
WOE FOR WAWRINKA
Cuevas had never beaten a top-four player before stepping out on court against Wawrinka, but needed just the two sets to put that record right.
The 16th seed from Uruguay did not face a solitary break point against the three-time grand slam champion in the first meeting between the two.
DJOKOVIC PASSES CARRENO BUSTA TEST
Djokovic was in danger of following Murray and Wawrinka out of the tournament, but hung in there to get past a defiant Carreno Busta and seal a clash with David Goffin.
It looked set to be plain sailing for the world number two when he won six games in a row to lead 2-0 in the second set, but the Spaniard was not finished yet.
Djokovic lost the next five games before Carreno Busta took it into a decider and the underdog had the Serb in trouble at 15-40 and 4-4 in the final set, but was unable to pull off a shock.
NADAL SPOILS THE PARTY
Nine-time Monte Carlo champion Nadal did not come bearing gifts on Zverev's 20th birthday, racing to victory in a one-sided contest.
The Spanish great broke five times as he won at a canter and will now face Diego Schwartzman, who reaches his first Masters quarter-final with a 6-3 6-0 demolition of Jan-Lennard Struff.
Lucas Pouille will take on Cuevas after the Frenchman was given an easy passage into the last eight, with compatriot Adrian Mannarino retiring due to a hip injury early in the first set.
|Centurion hero Ngidi aiming high|
|Mbappe: More to come from Neymar & Cavani partnership|
|Messi the greatest ever despite no World Cup win, insists Di Maria|
|Uncapped Larmour named in Ireland´s Six Nations squad|
|Villa determined to earn place in Spain´s World Cup squad|
|BREAKING NEWS: Walcott swaps Arsenal for Everton|
|Kohli bristles at selection questions|
|England forward Haskell handed four-week suspension|
|You even learn from Guardiola at home - Otamendi lauds Pep impact|
|Three-week ban for Bastareaud for alleged homophobic slur|
|IOC to consider joint Korean ice hockey team|
|Sri Lanka ODI woes drag on with Zimbabwe defeat|
|Batsmen let India down against South Africa - Kohli|
|Five fun facts as LeBron James chases 30K career points|
|Bastareaud named in France squad ahead of disciplinary hearing|
|Otamendi pens Man City deal to 2022|
|Neymar leads tributes to retiring Ronaldinho|
|Ronaldo must focus on playing - Zidane sidesteps exit talk|
|Dimitrov, Tsonga survive gruelling battles as Nadal cruises through|
|Carey ton sends Strikers back top of BBL|
|Zidane still an idol for James despite ´sad´ Madrid exit|
|Stoger will stay at Dortmund if ´everything fits´|
|Nadal backs move for financial parity but silent on boycott talk|
|Stokes available for England selection, set for NZ return|
|Bordeaux´s Malcom facing disciplinary action over social media video|
|Debutant Ngidi hurries SA to series win as India crumble in Centurion|
|Eddie Jones signs new England contract|
|Ronaldinho retires – The greatest Brazilians to play for Barcelona|
|England setting the benchmark in ODIs, says Warner|
|Federer would be unreal at any sport - Shapovalov|
|Athletic reward Williams with contract until 2025|
|Nadal too good for Mayer at Australian Open|
|Jones taking unlikely inspiration from City in United´s title pursuit|
|I had one foot out of the Australian Open – Wozniacki revels in fightback|
|Beware the nearly beaten in Melbourne – Wozniacki could match Kerber, Li|
|Rallying Tsonga outlasts Shapovalov in five-set epic|
|Wozniacki saves two match points in dramatic Aus Open comeback|
|Kostyuk, 15, ready to spend after Melbourne run|
|Thomas turns down Celtics´ video tribute|
|Moyes unaware of Chelsea interest in Carroll|
|Verdi wants Bologna stay amid Napoli links|
|Ronaldinho retires – A shining light of Brazil´s 2002 World Cup-winning team|
|Ronaldinho retires – a World Cup and Ballon d´Or among Brazil great´s prizes|
|Celtics great White dead at 71|
|World Cup glory and Bernabeu magic - Ronaldinho´s best moments for Barca and Brazil|
|Trust the Process – 76ers only behind Warriors and Cavs in merchandise sales|
|Ligue 1 Review: Balotelli at the double as Payet shines and Malcom toils|
|Pato still dreaming of World Cup selection|
|FA Cup Review: Iheanacho makes VAR history, kit confusion reigns|
|Wallaby saves wallaby: Farr-Jones in Sydney Harbour Bridge rescue mission|
|2016-17 UEFA Study: PSG, Man City drive record-breaking spending|
|Conte packing in homework as Chelsea games stack up|
|2016-17 UEFA Study: The headlines in transfers, wages and revenues|
|2016-17 UEFA Study: Manchester United record highest revenue but largest debt|
|Monaco stay perfect, Murcia overcome Oldenburg|
|Iheanacho scores English football´s first VAR goal|
|Materazzi not surprised by Coutinho transfer fee|
|Ronaldinho retires - Brazil and Barca great plans 2018 farewell|
|Jags RB Leonard Fournette uninjured in three-car accident|
|India revenge would heal Proteas´ scars - Elgar|
|Koziello swaps Nice for Cologne|
|Simeone ready to unleash Costa and Vitolo alongside Griezmann|
|Head coach Cooper to leave Stade Francais|
|Silverwood plays down talk of replacing Bayliss|
|Lambert ´never thought´ he would return to Premier League|
|Wenger ´very aggressive´ towards referee Dean, says FA report|
|Reported Arsenal target Malcom starts for Bordeaux vs Caen|
|Valverde not making big deal of Dembele´s latest Barca blow|
|Costly day for Kohli as Proteas close in on series win|
|Date set for Afghanistan´s maiden Test|