Andy Murray and Stan Wawrinka were bundled out of the Monte-Carlo Masters on Thursday, but Novak Djokovic and Rafael Nadal reached the quarter-finals in contrasting fashion.
Albert Ramos-Vinolas fought back from 4-0 down in the final set to claim the scalp of top seed Murray, who went down 2-6 6-2 7-5 on the clay in the principality.
The world number one was not the only big name to bow out, as US Open champion Wawrinka was beaten 6-4 6-4 by Pablo Cuevas.
Twelve-time grand slam champion Djokovic showed he still has work to do in order to return to the peak of his powers, but saw off Pablo Carreno Busta 6-2 4-6 6-4.
Fourth seed and defending champion Nadal only needed 68 minutes to beat birthday boy Alexander Zverev 6-1 6-1.
MURRAY RUES 'BAD DECISIONS'
Murray looked bound for the last eight when he won the first four games of the deciding set, but the three-time grand slam champion was left stunned by a defiant Ramos-Vinolas.
The top seed grew increasingly disgruntled in the final set as Spaniard Ramos-Vinolas turned the tide to seal the biggest victory of his career and book a last-eight meeting with Marin Cilic.
Wimbledon champion Murray said: "A few times, I made some bad decisions. That's something that, with my team, I'll look at, watch some parts of the match over, see the shots that I chose and what I would do differently."
WOE FOR WAWRINKA
Cuevas had never beaten a top-four player before stepping out on court against Wawrinka, but needed just the two sets to put that record right.
The 16th seed from Uruguay did not face a solitary break point against the three-time grand slam champion in the first meeting between the two.
DJOKOVIC PASSES CARRENO BUSTA TEST
Djokovic was in danger of following Murray and Wawrinka out of the tournament, but hung in there to get past a defiant Carreno Busta and seal a clash with David Goffin.
It looked set to be plain sailing for the world number two when he won six games in a row to lead 2-0 in the second set, but the Spaniard was not finished yet.
Djokovic lost the next five games before Carreno Busta took it into a decider and the underdog had the Serb in trouble at 15-40 and 4-4 in the final set, but was unable to pull off a shock.
NADAL SPOILS THE PARTY
Nine-time Monte Carlo champion Nadal did not come bearing gifts on Zverev's 20th birthday, racing to victory in a one-sided contest.
The Spanish great broke five times as he won at a canter and will now face Diego Schwartzman, who reaches his first Masters quarter-final with a 6-3 6-0 demolition of Jan-Lennard Struff.
Lucas Pouille will take on Cuevas after the Frenchman was given an easy passage into the last eight, with compatriot Adrian Mannarino retiring due to a hip injury early in the first set.
|Bellamy backs Coutinho´s Barcelona wish as Liverpool reportedly reject new £114m bid|
|Rooney deserves more credit, says record Everton signing Sigurdsson|
|Allegri challenges Dybala: I want an extraordinary season|
|Vuelta a Espana: History-hunter Froome no longer the sacrificial lamb|
|Boateng completes Frankfurt move|
|Burke one of many Crystal Palace targets, reveals De Boer|
|Guardiola offers sympathies to ´beautiful´ Barcelona|
|Keizer expects Tottenham target Sanchez to leave Ajax|
|PCB refutes ´baseless´ Umar Akmal allegations|
|Neymar ´one more player´ for PSG boss Emery|
|Vuelta a Espana: Retiring Contador´s career in Opta facts|
|Chelsea boss Conte envious of Tottenham´s foundation|
|Evans is a West Brom player - No transfer plea from Man City boss Guardiola|
|Bakayoko in contention for hasty Chelsea debut at Spurs|
|Manchester United are no dream team, warns Mourinho|
|Jose Mourinho accepts defeat in hunt for fourth Manchester United signing|
|Pochettino wants four Tottenham signings before transfer window closes|
|Kayode loaned to Girona after joining Manchester City|
|Conte bursts out laughing over Costa´s ´criminal´ treatment claim|
|Costa: Chelsea return would not be fair situation|
|Juventus boss Allegri sees ´five or six´ teams in Scudetto race|
|Broncos battle to dent Dragons´ play-off ambitions|
|Barcelona, Real Madrid hold minute´s silence for Las Ramblas victims|
|Diego Costa is not an Atletico player - Simeone unmoved on Chelsea star|
|Costa accuses Chelsea of pricing him out of Atletico Madrid move|
|Armstrong signs new Cetlic deal to end speculation|
|Serie A 2017-18: Ambitious AC Milan set sights on Juventus dominance|
|Frankfurt medical for Boateng after Las Palmas exit|
|Castro shocked by Dembele as Dortmund star pushes for Barcelona move|
|Australia v New Zealand: Everything you need to know|
|Defoe pushing for start against Watford|
|Jese Rodriguez set to make Stoke debut against Arsenal|
|Read defends All Blacks security guard cleared over ´bug-gate´|
|West Brom don´t need to sell Evans - Pulis responds to Manchester City bid|
|Matic in Chelsea dig: Manchester United are definitely bigger|
|Serie A 2017-18: Shock signing Bonucci, Juve star Dybala - five stars to watch|
|Bilic ´sure´ Liverpool target Lanzini is staying at West Ham|
|Starc rested from India tour with Ashes in mind|
|Bailly: Manchester United will prove world-class status this season|
|Nationals owner Lerner has leg amputated amid cancer battle|
|Rockies´ Blackmon leads a night of bizarre accomplishments|
|Wallabies captain Hooper dreaming of Bledisloe Cup success|
|Halep cruises, Muguruza saves match points as rain washes out play|
|Thiem, Dimitrov reach quarters in rainy Cincinnati|
|Klopp: No reason to leave Liverpool as Barca eye Coutinho|
|Montella happy with Milan progress|
|LeBron shows off new Goodyear Cavs jersey|
|United signing Matic from Chelsea a masterstroke - Robson|
|Durant: Irving situation not the end of the world for Cavs|
|Milan in ´advanced´ talks to sign Kalinic, Fassone tight-lipped on Ibrahimovic|
|Mayweather says he´s going ´straight ahead´ at McGregor|
|Centurion Root hails ´ruthless´ England after first day-night Test|
|Every sets early pace at Wyndham Championship|
|Barcelona to honour terror victims in LaLiga opener|
|Europa League Review: AC Milan on fire, Athletic Bilbao in stirring comeback and Fenerbahce suffer s|
|We were lucky - Koeman frustrated by Everton´s second-half struggle|
|DeMaurice Smith says NFL work stoppage in 2021 ´a virtual certainty´|
|Carroll hails Britt as center signs new three-year deal with Seahawks|
|Bonucci revels in ´wonderful´ San Siro bow as AC Milan destroy Shkendija|
|Classy Castleford secure League Leaders´ Shield|
|Everton 2 Hajduk Split 0: Keane opens account in comfortable Europa League win|
|AC Milan hit 24-year high in Shkendija thrashing|
|Hard day-night for Windies as Cook and Root dominate|
|AC Milan 6 Shkendija 0: Silva, Montolivo inspire Rossoneri to brink of Europa League group stage|
|Lyth thumps 161 as Yorkshire plunder 260 in T20|
|Messi, Ronaldo and Suarez lead tributes as football stands with Barcelona|
|Usain Bolt offered burgers and beer to join Portuguese football club|
|Hummels joins Mata in pledging one per cent of his wages to charity|
|Carroll poised for West Ham return at Newcastle|
|Arsenal´s Alexis Sanchez named in latest Chile squad|