Leeds United moved top of the Championship with a 2-0 win over Birmingham City as they became the only unbeaten side left in the division on Tuesday.
Previous leaders Cardiff City were thrashed 3-0 at Preston North End to end their unblemished start to the campaign, with Thomas Christiansen's men taking their place at the summit.
Goals from Samuel Saiz and Stuart Dallas condemned Harry Redknapp's side to a fifth defeat in seven league games, leaving the Blues in the bottom three.
Josh Harrop's double – including a fine free-kick to break the deadlock – and one from Alan Browne wrapped up the points for Preston, who joined the two Sheffield clubs and Wolves in the play-off spots of the embryonic table.
Wednesday's 2-1 victory against winless Brentford at Hillsborough involved 17 minutes of stoppage time following an injury for Henrik Dalsgaard, while city rivals United were indebted to debutant Cameron Carter-Vickers' decisive strike against rock-bottom Bolton Wanderers.
Despite shaping up as one of the headline clashes of the night, Middlesbrough's trip to Aston Villa ended goalless as both sides had a man sent off.
Adama Traore was dismissed just three minutes into his return to Villa Park for a foul on Conor Hourihane, but Henri Lansbury was also given his marching orders in the second half to even it up.
Hourihane thought he had won it 15 minutes from time, but his goal-bound effort was blocked on the line by team-mate Scott Hogan.
Molineux played host to a six-goal thriller as Wolves and Bristol City shared the spoils from an entertaining affair, which stood in stark contrast to Norwich City's 0-0 draw with Burton Albion.
Elsewhere, Daryl Murphy's goal sealed a 1-0 victory for Nottingham Forest at under-performing Sunderland, while QPR came from two goals down to draw 2-2 with 10-man Millwall at Loftus Road.
|Zidane not worried after Madrid lose ground on Barca|
|Casemiro calls for Madrid calm after shock Betis loss|
|Sane sends message to Guardiola as Manchester City shake off West Brom|
|Keep calm and carry on – Allegri backs Higuain to rediscover scoring touch|
|Bosz proud of table-topping Dortmund after Hamburg triumph|
|Marlins slugger Stanton crushes 56th home run|
|Montella points to schedule after uninspired Milan win|
|Conte confirms Luiz will be fit to face Atletico|
|Manchester City boss Guardiola hopeful Gundogan injury not serious|
|Real Madrid 0 Real Betis 1: Ronaldo´s return ruined as Sanabria stuns LaLiga champions|
|Wilshere is ready for the league - Wenger|
|Simeone lauds ´different class´ Griezmann|
|Mourinho praises United´s professionalism in EFL Cup win|
|Spurs to host West Ham in EFL Cup fourth round|
|Froome: Time to put my feet up|
|West Brom 1 Manchester City 2: Sane at the double amid fresh Gundogan fears|
|Manchester United 4 Burton Albion 1: Mourinho´s men begin EFL Cup defence in style|
|Arsenal 1 Doncaster Rovers 0: Walcott hits winner for Wenger´s men|
|AC Milan 2 SPAL 0: Penalty double seals comfortable win for Montella´s side|
|Chelsea 5 Nottingham Forest 1: Hazard on form as Batshuayi claims hat-trick|
|Juventus 1 Fiorentina 0: Mandzukic on target as Bianconeri maintain winning start|
|Returning Gundogan limps out of impressive Manchester City return|
|Hamburg 0 Borussia Dortmund 3: Bosz´s men cruise back to Bundesliga summit|
|Broady stuns Mannarino in St Petersburg|
|Athletic Bilbao 1 Atletico Madrid 2: Correa and Carrasco strike in second-half surge|
|Simon suffers surprise Moselle Open exit as home hopes struggle in Metz|
|South Africa announce India schedule and planned four-day Zimbabwe Test|
|I have nothing to prove - Paulinho|
|Prodl pens new four-year Watford contract|
|Monaco renew Subasic, Raggi deals|
|Stoneman is ready for Ashes test - Cook|
|Sampson sacked as England Women´s boss|
|Manchester United to act against ´offensive behaviour´ after Lukaku race row|
|Atletico Madrid´s Wanda Metropolitano to host 2019 Champions League final|
|Flying Dutchman Dumoulin crowned world champion|
|Wickmayer topples Peng in Guangzhou, Hogenkamp makes Seoul progress|
|Solomona focused on Sale rather than England return|
|‘Raging Bull’ Jake LaMotta dies aged 95|
|Chelsea confident of recruitment compliance amid FIFA investigation|
|Brighton seal permanent signing of Newcastle keeper Krul|
|Louw, Nkosi and Schreuder get Springboks call|
|Perez donates 3m pesos to Mexico earthquake fund|
|Injured Mathews out of opening Pakistan Test|
|Double leg break victim Rossi to attempt incredible Aragon GP return|
|Barcelona condemn Spanish crackdown on Catalonia independence vote|
|Muguruza marches past Puig, Pliskova and Kerber progress in Tokyo|
|Benzema seals Real Madrid stay until 2021|
|Smith defends captaincy ahead of landmark ODI|
|Perisic promised Inter can match Manchester United|
|The race is on - Aubameyang lays down Lewandowski challenge|
|Cristiano Ronaldo´s Real Madrid return confirmed|
|Bellew tells Haye ´I oblige you´|
|Mbappe can prove he´s ready for Madrid at PSG - Morientes|
|Five-year ban for Pakistan batsman Latif|
|PSG ´destroyed the market´ with Neymar and Mbappe - Elber|
|Bulldogs chairman says sacked Hasler will not be compensated|
|Coutinho withdrawal inspired Leicester to victory, claims Shakespeare|
|Windies opener Brathwaite cleared to bowl|
|Valverde hopes Suarez benefits from Eibar rest|
|Wilshere returning to his best form - Wenger|
|Yankees, Cardinals keep pace in postseason race|
|Klopp: Liverpool are still a good football team|
|Pochettino hails ´top player´ Alli|
|Messi from ´another planet´, says Semedo|
|James performance pleases Ancelotti|
|Gordon´s homer breaks MLB single-season home run record|
|Spieth feeling good ahead of Tour Championship|
|Thomas unsurprised by stunning season|
|Lakers confirm Bogut signing|
|Maestro Messi brings up 300 Camp Nou goals|